Detalhe da pesquisa
1.
Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis.
Nature
; 560(7717): 192-197, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30046105
2.
Author Correction: Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis.
Nature
; 619(7970): E48, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37402863
3.
Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.
Proc Natl Acad Sci U S A
; 116(19): 9318-9323, 2019 05 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30962368
4.
A newly classified vertebrate calpain protease, directly ancestral to CAPN1 and 2, episodically evolved a restricted physiological function in placental mammals.
Mol Biol Evol
; 27(8): 1886-902, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20223856
5.
Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis.
J Med Chem
; 64(9): 5905-5930, 2021 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33904304
6.
Regulation of plant gene expression by alternative splicing.
Biochem Soc Trans
; 38(2): 667-71, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20298240
7.
The Qi Site of Cytochrome b is a Promiscuous Drug Target in Trypanosoma cruzi and Leishmania donovani.
ACS Infect Dis
; 6(3): 515-528, 2020 03 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31967783
8.
Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent In Vitro Antileishmanial Activity: Initial SAR and Assessment of In Vivo Activity.
J Med Chem
; 63(17): 9523-9539, 2020 09 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32663005
9.
Identification of 6-amino-1H-pyrazolo[3,4-d]pyrimidines with in vivo efficacy against visceral leishmaniasis.
RSC Med Chem
; 11(10): 1168-1177, 2020 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33479621
10.
Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani.
ACS Infect Dis
; 5(1): 111-122, 2019 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30380837
11.
Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis.
J Med Chem
; 62(3): 1180-1202, 2019 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30570265
12.
Deletion of the TbALG3 gene demonstrates site-specific N-glycosylation and N-glycan processing in Trypanosoma brucei.
Glycobiology
; 18(5): 367-83, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18263655
13.
Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani.
ACS Infect Dis
; 3(10): 718-727, 2017 10 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28967262
14.
Development and Validation of a Novel Leishmania donovani Screening Cascade for High-Throughput Screening Using a Novel Axenic Assay with High Predictivity of Leishmanicidal Intracellular Activity.
PLoS Negl Trop Dis
; 9(9): e0004094, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26407168
15.
Characterisation of capn1, capn2-like, capn3 and capn11 genes in Atlantic halibut (Hippoglossus hippoglossus L.): Transcriptional regulation across tissues and in skeletal muscle at distinct nutritional states.
Gene
; 453(1-2): 45-58, 2010 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20093171
16.
Plasticity of muscle fibre number in seawater stages of Atlantic salmon in response to photoperiod manipulation.
J Exp Biol
; 206(Pt 19): 3425-35, 2003 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-12939373
17.
Freshwater environment affects growth rate and muscle fibre recruitment in seawater stages of Atlantic salmon (Salmo salar L.).
J Exp Biol
; 206(Pt 8): 1337-51, 2003 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-12624169